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Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril by UV-Spectrophotometric Method in Pharmaceutical Dosage Form Vanaja N., Preethi Ch., Dr. Manjunath S.Y., Pal Krishanu Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velkatta, Telangana-502277 *Corresponding Author E-mail:
Online published on 29 January, 2016. Abstract The present work was aimed at method development and validation for simultaneous estimation of Telmisartan and Ramipril by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and λ max of Telmisartan and Ramipril were found to be 232nm and 222nm respectively. Concentration ranges were found to be 4–20μg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Telmisartan and Ramipril respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95–105% for Telmisartan and Ramipril. LOD and LOQ ranges were found to be 0.177 and 0.539μg/mL and 0.298 and 0.903μg/mL for Telmisartan and Ramipril respectively. This method was validated using ICH guidelines. Top Keywords Telmisartan, Ramipril, UV-Spectrophotometric method, Simultaneous equation, Validation. Top | |
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