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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 3
First page : ( 142) Last page : ( 146)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00023.X

Estimation of Venlafaxine in Commercial Dosage Forms Using Simple and Convenient Spectrophotometric Method

Pathan Humera1, Baokar Shrikrishna1,*, Santosh Undare2, Patil R.N.1

1Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal's College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra, India, 413115

2PG, Department of Chemistry, Marathwada Shikshan Prasarak Mandal's Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India, 431112

*Corresponding Author E-mail: krishnabaokar@gmail.com

Online published on 8 December, 2015.

Abstract

Venlafaxine belongs to a group of Antidepressant with a novel chemical structure. In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of absorbance of Venlafaxine hydrochloride solution in 0.1N NaOH at 225 nm. The method obeys Beer's Lambert's law in the selected concentration range 5–25 μg/ml in selected solvent. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of venlafaxine hydrochloride in bulk and pharmaceutical formulations.

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Keywords

UV-visible spectrophotometer, Method development, Venlafaxine hydrochloride.

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