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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 3
First page : ( 115) Last page : ( 118)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00018.6

Development and Validation of RP-HPLC Method for Simultaneous Estimation of Albendazole and Praziqantel in Tablet Dosage Form

Gandla Kumaraswamy1,*, Lalitha R.1, Bommakanti Sadhana1, Suthakaran R.1, Pallavi K.2

1Department of Pharmaceutical Analysis, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-505172, Telangana

2SSJ College of Pharmacy, Vattinagulpalli, Hyderabad, Telangana

*Corresponding Author E-mail: kumaraswamy.gandla@gmail.com

Online published on 8 December, 2015.

Abstract

A Simple, specific and sensitive an isocratic simultaneous Estimation by RP-HPLC analytical Method were developed and validated for the quantification Albendazole and Praziqantel. Quantification was achieved by using the mobile phase Phosphate Buffer pH 4.0: Acetonitrile and Methanol in the ratio of 20: 70: 10 Inertsil ODS, C-18, 250×4.6mm ID, 5μm Particle size was used as stationary phase. The flow rate was 1.0 ml/min. Measurements were made at a wavelength of 238nm. The average retention times for Albendazole and Praziqantel was found to be 2.713 and 4.770min. The proposed method was validated for selectivity, precision, linearity and accuracy. The assay methods were found to be linear from 60–180μg/ml and5-15μg/ml for Albendazole and Praziqantel respectively. All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of Albendazole and Praziqantel.

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Keywords

Albendazole and Praziqantel, RP-HPLC method, isocratic elution Tablet dosage forms.

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