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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 2
First page : ( 100) Last page : ( 104)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00016.2

New Spectroscopic Method for Estimation of Atorvastatin Tablets Using Hydrotropic Solubilization Technique

Dr. Rani N. Usha*, Keerthana K, Mitha M, Kumar Santhosh S, Kotamma K, Kiran T.M.N.U.

Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram-535002, AP, India

*Corresponding Author E-mail: nusharani.au@gmail.com

Online published on 29 October, 2015.

Abstract

A new, simple, accurate, cost effective and sensitive spectrophotometric method has been developed for the estimation of Atorvastatin (ATV) in tablet dosage form using 0.5 M sodium benzoate aqueous solution as a hydrotropic agent. Aqueous solubility of this model drug was enhanced 22 fold with 0.5M sodium benzoate solution without any interference with the method of analysis. Atorvastatin (ATV) showed maximum absorbance at a wavelength of 268 nm and Beer's law was obeyed in the concentration range of 0.1–0.6 μg/ml. The method was validated for various parameters according to ICH guidelines. Hence it can be adopted for the routine analysis of Atorvastatin (ATV) in tablet dosage forms.

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Keywords

Atorvastatin, Hydrotropic solubilization, Method development and Validation.

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