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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 2
First page : ( 61) Last page : ( 66)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00010.1

Estimation of Ranitidine in Bulk and Formulation by First Order Derivative Area under Curve UV-Spectrophotometry Methods

Mali Audumbar Digambar*, Manojkumar Patil

Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India

*Corresponding Author E-mail: maliaudu442@gmail.com

Online published on 29 October, 2015.


Simple, fast and reliable spectrophotometric methods were developed for determination of Ranitidine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the first order Derivative Area under Curve method values measured at 329-335nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Ranitidine using 2–10μg/ml (r2=0.999) for first order Derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Ranitidine in pharmaceutical formulations.



Ranitidine, First order Derivative, Area under Curve (AUC).


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