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Asian Journal of Pharmaceutical Analysis
Year : 2013, Volume : 3, Issue : 4
First page : ( 115) Last page : ( 118)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.

RP-HPLC Analysis for Quantitation of Candesartan Cilexetil in Solid Dosage Forms

Revathi R.1,*, Saravanan V.S.1, Ethiraj T.2, Marreddy Jhansi Lakshmi1

1Department of Pharmaceutical Analysis, The Erode College of Pharmacy and Research, Erode, Tamil Nadu, India

2Department of Pharmaceutics, The Erode College of Pharmacy and Research, Erode, Tamil Nadu, India

*Corresponding Author E-mail revathethiraj@gmail.com

Online published on 19 June, 2014.

Abstract

A simple reverse phase liquid chromatographic method was developed and validated as per the ICH guidelines for the quantitative determination of candesartan cilexetil in pharmaceutical dosage forms. The mobile phase consisted of 0.02 M mono basic potassium phosphate buffer: acetonitrile: triethyl amine (40:60:0.2) and adjust pH to 6.0 with ortho phosphoric acid. The eluent was monitored at 254 nm, at a flow rate of 2 mL/min and retention time was observed at 9.153 min. The linearity was observed from 0.08071–0.24213 mg/mL with R2= 0.998. The LOD and LOQ were found to be 0.00005 mg/mL and 0.00017 mg/mL respectively. This method was also validated and can be successfully applied for routine analysis.

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Keywords

Candesartan cilexetil, RP-HPLC, Validation.

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