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Asian Journal of Pharmaceutical Analysis
Year : 2013, Volume : 3, Issue : 1
First page : ( 3) Last page : ( 8)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.

Validated Non-Extractive Spectrophotometric Methods for Determination of Some Angiotensin II Receptor Antagonists

El-Sutohy Mohamed M.1,*, El-Shaboury Salwa R.2, Hussein Samiha A.2, Mohamed Niveen A.2

1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt

2Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

*Corresponding Author E-mail: mohamed_mounir2000@yahoo.com

Online published on 19 June, 2014.

Abstract

Two simple, rapid, sensitive, accurate and non-extractive spectrophotometric methods have been developed for determination of some angiotensin II receptor antagonists (AIIRA's) namely Losartan potassium (Los-K) and Irbesartan in pure forms as well as in their pharmaceutical dosage forms. The methods were based on using chloroformic solutions of either Bromcresol purple (BCP) or Cresol red (CR) for determination of the cited drugs giving highly coloured complexes that measured at 415 nm or 435 nm for both methods respectively. Different variables affecting the reactions were studied and optimized. Under the optimum reactions conditions, linear relationships with good correlation coefficients (0.9960–0.9999) were obtained over the concentration ranges of 2–50 μg/ml. Good accuracy and precision were successfully obtained for the analysis of tablets containing each drug alone or combined with other diuretic drug Hydrochlorothiazide (HCTZ). No interferences could be observed from the coformulated HCTZ as well as the commonly encountered excipeints present in tablets.

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Keywords

Spectrophotometry, angiotensin II receptor antagonists, analysis, Losartan potassium, Irbesartan.

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