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Asian Journal of Pharmaceutical Analysis
Year : 2020, Volume : 10, Issue : 1
First page : ( 07) Last page : ( 10)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2020.00002.2

UHPLC-PDA Method for Simultaneous Determination of Sartans Antihypertensive Drugs

Khan Hamid*

Rungta Institute of Pharmaceutical Sciences, Bhilai, Chhattisgarh, India

*Corresponding Author E-mail: khanhamid770@gmail.com

Online published on 3 June, 2020.


In the presented work the Ultra-high performance Liquid Chromatographic-Photodiode Array Detection (UHPLC-PDA) method has been developed and validated for Simultaneous determination of Sartans Antihypertensive Drugs such as Losartan, Telmisartan, Valsartan, Candesartan, Irbesartan and Olmesartan. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50: 50, v/v) at a flow rate of 0.25 mL/min. The Detection of all the drugs was carried out by PDA detector at 245 nm. The method was applied for routine quality control analysis and pharmacokinetic study of these drugs in human plasma.



UPLC-PDA, Antihypertensive Drugs, ARBs, Sartans, Determination.


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