Department of Pharmaceutics, University of Technology, Osmania University, Hyderabad, Telangana
Emulsion cross linking method can be successfully employed to fabricate Nizatidine microspheres than Ionotropic gelation method. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of polymer, uneasy in dropping through syringe, air pollution, toxicity and difficult to remove traces during filtration. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range 540μm to 644μm. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Nizatidine using chitosan as polymer and glutaraldehyde as cross linking agent adhered to the mucus to a greater extent than sodium alginate along with Carbopol934. The invitro drug release decreased with increase in the polymer and copolymer concentration.
Nizatidine, Mucoadhesion, Ionotropic gelation method
