Effect of Annona squamosa, Bacopa monneri and Baliospermum montanum alcoholic extracts on bacterial enzymes in 1, 2-dimethyl hydrazine induced Colon Cancer in rats.
Abstract
The intestinal microflora may play a significant role in the pathogenesis of colon cancer. Differences in composition and concentrations of some fecal and colon bacterial enzymes were initially reported in low compared to high risk colon cancer groups. Activity of colon biotransforming enzymes were considered to be hallmarks of colon carcinogenesis. Annona squamosa, Bacopa monneri and Baliospermum montanum show various pharmacological and biological activities. Our present study shows the effect of alcoholic extracts of Annona squamosa, Bacopa Monneri and Baliospermum montanum administration on 1, 2-dimethylhydrazine induced colon cancer in rat colon, and fecal and mucosal biotransforming enzyme activities. A total of 42 rats were randomized into seven groups. Administration of alcoholic extracts of Annona squamosa 300mg/kg b.wt, Bacopa monneri 300mg/kg b.wt and Baliospermum montanum 200mg/kg b.wt lowered the activities ofcolon, fecal and mucosal bio-transforming enzymes. Our findings suggest that these extracts may be possible chemopreventive agents against colon cancer.
Keywords
Colon cancer, Bacterial enzymes, DMH, Mucinase, β-glucuronidase, β-glucosidase
