Poor aqueous solubility of a drug is an industry wide issue for pharmaceutical scientists in dosage form development. Numerous approaches have been developed for solubility enhancement of biopharmaceutical class II drugs (low solubility and high permeability). Obviously poorly water soluble drugs show many problems in formulating them in dosage forms. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. As about 70% of the human body is made up of water, a drug must be water-soluble and thus possess an acceptable bioavailability level. Therefore, the improvement of drug solubility thereby its oral bioavailability remains one of most challenging aspects of drug development process especially for oral drug delivery system. As the size of the solid particle influences the solubility because the particle becomes smaller, the surface area to volume ratio increases. The larger surface area allows a greater interaction with the solvent, so, the micronization is most important in this point of view to enhance the solubility and bioavailability. There are numerous approaches available and reported in review to enhance the solubility of poorly water soluble drugs.
Micronization, solubility, bioavailability, nanotechnology, super critical fluid
