1Maharashtra Academy of Engineering And Educational Research's, Maharashtra Institute of Pharmacy, S.No.124, MIT Campus, Paud Road, Pune-411038, Maharashtra, India.
2Department of Chemistry, University of Pune, Pune-411007, Maharashtra, India.
3J.S.P.M.’s Jayawantrao Sawant College of Pharmacy & Research Hadapsar, Pune-411028, Maharashtra, India.
Present work describes the synthesis of (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, derivatives of Chalcones. Starting material 8-hydroxy quinoline was acetylated and subjected to fries rearrangement reaction to yield 7acetaldehyde-8-hydroxy quinoline which on aldol condensation with various derivatives of benzaldehyde yields 13 compounds. The compounds have been characterized and evaluated for anti-bacterial activity. MIC values of the compounds showing higher zone of inhibition was found to be 100 μg/ml. The activity of the compounds can be attributed to the substitution of electronegative groups in the synthesized compounds.
anti-bacterial activity, benzaldehyde, Chalcone, electronegative, 8-hydroxyquinoline
