Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis of Some New Bioactive Chalcones and Flavones

  • Author:
  • SS Mokle, MA Sayyed, AY Vibhute, SV Khansole, YS Nalwar, YB Vibhute
  • Total Page Count: 4
  • DOI:
  • Page Number: 846 to 849

Laboratory of Organic Synthesis, P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.)

Abstract

New chalcones (3a-g) were synthesized from 5-chloro-2-methoxybenzaldehyde (2) and halohydroxysubstitued acetophenones (1a-g) via Claisen-Schmidt condensation. Further new flavones (4a-g) were synthesized by oxidative cyclisation of chalcones (3a-g).The structure of synthetic compounds were confirmed by IR, 1H NMR and elemental analysis. These compounds were screened for their antibacterial activity and studied the effect on seed germination of wheat (Triticum aestivum).

Keywords

Chalcones, flavones, antibacterial activity, seed germination of wheat