RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

In the present work, the preliminary phytochemical study and in vitro thrombolytic activity was conducted for Terminalia pallida Brandis leaves extract. In vitro thrombolytic was evaluated by clot lysis effect of different solvent extracts of Terminalia pallida Brandis leaves. In this study, streptokinase and distilled water were used as positive control and negative control, respectively. In vitro thrombolytic model of methanolic extract showed maximum clot lysis (95.43%±0.697) at test concentration (800μg/ml) in 72 hrs. Hydro alcoholic extract also showed potential clot lysis (90.43%±0.748) at similar test conditions. In addition, other plant extracts such as petroleum ether, ethyl acetate, chloroform extract showed moderate activity at 800 μg/ml concentration i.e., 65.56%±0.984, 70.16%±0.325 and 72.98%±0.985 clot lysis, respectively in 72 hrs. Streptokinase (SK) and water showed clot lysis maximum of 97.26%±0.974 and 41.33%±0.843 respectively. The present study reveals that the methanolic and hydro alcoholic extracts of Terminalia pallida Brandis leaves possesses potential thrombolytic activity.