RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 1

Synthesis, characterization and antifungal evaluation of substituted pyrimidin-2-thione derivatives

  • Author:
  • Shradha Pandey1*, Prateek Pandey2, Singh Shekhar Gautam2, Jagdamba Singh1
  • Total Page Count: 5
  • Page Number: 275 to 279

1Environmentally Benign Laboratory, Dept. of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India.

2United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India.

Abstract

Pyrimidine and its thione derivatives have found a wide range of application in medicine due to their pronounced biological activity. An attempt has been made to combine the toxophoric qualities of biologically versatile 2-amino-4-aryl thiazole and 5-arylidene-3-aryl rhodanine moieties and synthesizing pyrimidin-2-thione derivatives, VII(a-j). The compounds were screened for their in vitro antifungal potential against Aspergillus niger and Fusarium oxysporium. The results were promising as the compounds VII b, VII c, VII g and VII h displayed fungicidal action equivalent to that of commercial fungicide Dithane M-45 at 1000 ppm concentration.

Keywords

Pyrimidine, Thione, Rhodanine, Fungicides, 2-amino-4-aryl thiazole, Agar-plate