RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

The present study was aimed to develop sustained release floating tablet containing lisinopril by wet granulation technique. HPMC K4 M and Carbopol 934 P were used to sustain the drug release. The results of micromeretic properties of granules showed good flow behavior. Tablet weight variation, friability and drug content were within the specified limits. Tablet hardness and thickness were satisfactory. The tablets were hydrated gradually reaching a plateau after 8 h. The floating lag time varied from 22.9–68.6 seconds depending on polymer type and concentration. The in vitro drug release profile of tablets containing crosprovidone at its higher level and HPMC alone showed more than 50% of cumulative percentage drug release at the end of first 4 h of the dissolution study. However, from these tablets, at the end of 8 h the cumulative percentage drug release was found to be 71.03±4.975%. Formulations F11 containing HPMC K4M and Carbopol 934 and higher level of Croscarmellose sodium showed a higher percentage of drug release (79.15±2.688%) when compared to the other formulations. The developed floating system enhanced the retention time and prolonged the drug release in 0.1 N HCl (pH 1.2), which could improve the local availability of the drug.