Research Journal of Pharmacy and Technology

The present investigation concerns the development of immediate release tablet of Raloxifene Hydrochloride by Hot Melt Technology using hydrophilic polymer in various ratio. Seven batch of hot melt were fabricated containing Raloxifene Hydrochloride and Polyethylene Glycol. From the all batch of hot melt one batch were selected for formulation of immediate release tablet. Raloxifene Hydrochloride immediate release tablet was prepared, by using polyplasdone a super disintegrant and pharmatose 200m as a filler. Preformulation study was performed like Angle of repose, Bulk density, Tapped density, Carr's index Hausner ratio. Tablet were prepared by wet granulation technique, the evaluation study were performed like hardness, thickness, friability, assay, content uniformity, weight variation, disintegration time, in-vitro drug release and stability. Seven formulation were prepared, Formulation F6 (Raloxifene Hydrochloride and Polyethylene Glycol in ratio 1:0.5) were optimized, having similar disintegration time and in vitro release profile compare to reference.