Research Journal of Pharmacy and Technology

A key goal in pharmacological screening is a good understanding of the in vivo performance. So development of in vitro evaluations that could be correlated to in vivo performance would be commendable. The purpose of this research was to develop easily predictable in vitro method for the evaluation of antiinflammatory activity. Further, this research work was also aimed to establish an in vitro -in vivo correlation of anti-inflammatory activity.

Kappa-carrageenan was used to induce inflammation on the chicken intestine. We proposed a new apparatus which we name ‘Jijith-Jayakumari apparatus’ for the in vitro evaluation of anti-inflammatory agents. Diclofenac sodium was used as the model drug.

The developed in vitro method using chicken intestine was worth for screening ant-inflammatory activities. A good correlation was obtained between in vitro and in vivo data. Thus, an IVIVC was established for antiinflammatory activity.