Research Journal of Pharmacy and Technology

New, simple, selective and cost-effective method has been developed for the determination of Vildagliptin in bulk and in pharmaceutical dosage forms. The method is based on the formation of a Schiff base with pdimethylaminobenzaldehyde (PDAB) in acidic ethanol; the reaction of drug with reagent gives a bright yellow colour. The formed coloured species absorbance was measured at its absorption maximum λmax 446 nm. All the variables were studied to optimize the reaction conditions. The Beer's law has been obeyed in the concentration range 75–175 μg/ml with correlation coefficient (R²= 0.9977). The LOD and LOQ of the proposed method were calculated 10.633 (μg/ml), 32.223 (μg/ml) respectively. No interference was observed in the presence of common pharmaceutical excipients.