Research Journal of Pharmacy and Technology

In the present work polymeric nano-fiber patches were developed for the effective treatment of skin infection using cephalexin as model drugs. The nano-fibers were prepared by electro spinning technique by using polyvinyl alcohol (PVA) as a polymer and fibers were characterized on the basis of entrapment efficiency, fiber diameter, morphology, x-ray diffraction analysis, drug release behavior and in vitro antimicrobial test. The entrapment efficiency of the optimized formulation was 95%. The % cumulative release of drug from nano-fiber patch across the dialysis membrane was 96% at the end of 24h. The ex-vivo release of drug through nano-fiber patch across the goat skin was 81% at the end of 24 h.