1Department of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502
2Department of Pharmacology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh-534202
Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. There is evidence that brain tissue in patients with AD is exposed to oxidative stress during the course of the disease. Conessine is a natural steroidal glycoside, which has been reported to exert various biological activities such as antioxidant and anti-inflammatory effect.
The present study aimed to investigate the effects of Conessine on neurobehavioral activity and superoxide dismutase (SOD), glutathione reductase (GRx) and catalase (CAT) enzymes activity, malondialdehyde (MDA) levels in hippocampal area of rats in an experimental model of AD.
The AD was induced in animals by intracerebroventricular injection of STZ (icv-STZ) unilaterally. Animals were treated with the Conessine (20 mg/kg body weight), then after three successive weeks, recognition memory was examined (passive avoidance test and novel object recognition test) and antioxidant parameters were evaluated.
In our study behavioural testes showed improvement on memory retrieval and recognition memory consolidation. Furthermore the Conessine increased the activity of antioxidant enzymes SOD, glutathione GRx and CAT levels and decreased MDA in the hippocampal area.
These results suggested that Conessine may inhibit STZ-induced oxidative stress, and that it may possess therapeutic potential for the treatment of AD.
Alzheimer's, Oxidative stress, Memory, anti oxidant, Conessine
