Research Journal of Pharmacy and Technology

Loratadine, histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Administration of Loratadine through oral route is a challenge in children, who have difficulty to swallow tablets. In the present study, nine batches of Loratadine Mouth Dissolving tablets (MDTs) dosage form at the dose of 10 mg were formulated and evaluated. Results showed that thickness, weight variation, friability, hardness, and content uniformity of all five formulations were within the acceptable limits. But in the in-vitro dissolution study, formulation 7, 8 and 9 demonstrated better cumulative drug release than formulation 3 and 6. However, cumulative drug release of formulation 9 was comparable with innovator than formulation 3 and 6. Three month stability study of formulation 9 revealed that there were no significant change in physical parameters, drug content and dissolution profile. Hence the study concludes that Loratadine mouth dissolving tablets formulated using starch-1500 and microcrystalline cellulose (Formulation 9) showed better characteristics of mouth dissolving tablets.