1Department of Medicinal Chemistry, Institute of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Uttar Pradesh, India
2Acharya Narendra Dev College of Pharmacy, Babhnan, Gonda-271313, Uttar Pradesh, India
Synthesis and Evaluation of Ulcerogenic potential for NSAID-Alendronate based prodrug.
Three NSAIDs (Diclofenac, Indomethacin and Ibuprofen) were conjugated with Alendronate though amide linkage. The synthesized prodrugs were evaluated for their ulcerogenic potential on wistar rats at the dose of 25, 50 and 100mg/kg.
The severity index for the group administered with the parent drugs was in the range of ∼ 1–2.7. However, the severity index for the group administered with the prodrug was in the range of ∼0.5 to 1.8.
The newly reported prodrugs showed significantly less signs of ulcerogencity.
NSAID, Bisphosphonate, Prodrug, Ulcer, Combination
