1Professor, Head of Biochemistry Unit Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala, Terengganu, Malaysia.
2President, Al-Kausar Tibb-E-Nabuvi Research Foundation Trust, Vaniyambadi, India.
3Associate Professor, Department of Biotechnology, Thiruvalluvar University, Vellore, India.
4Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.
5Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia.
6Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia43400, UPM, Serdang, Selangor, Malaysia.
7Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, UPM, Selangor, Malaysia.
The study was performed to assess the antidiabetic properties of a polyherbal formulation (
Healthy, male Wistar rats were studied. The rodents were separated into four groups. Group I used as positive control and Group II as negative control. Group III was diabetic rats treated with
Body weight, food and fluid intake were recorded periodically. OGTT was performed. The biochemical analysis accomplished includes fasting blood glucose, C-peptide, HbA1c, plasma insulin, and urine sugar. Insulin resistance (IR), β-cell function and insulin sensitivity were also manipulated from HOMA-IR and HOMA β-cell function.
The findings of the experiment distinctly indicate that the polyherbal formulation has significantly reduced the readings of fasting blood glucose (FBG) and HbA1c.
The results obtained postulated that the
Kasini ashshifa, Polyherbal, Antidiabetic, insulin resistance, C-peptide
