1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tishreen University, Lattakia, Syria. zen.khdar@hotmail.com
2Department of Pharmaceutical Chemistry, Faculty of pharmacy, Tartous University, Syria
3Department of Pharmaceutical Chemistry, Faculty of pharmacy, Tishreen University, Lattakia, Syria, mohammadkousara@tishreen.edu.sy
Pim-1 (Proviral Insertion site of Molony Murine Leukemia virus) kinases is an oncogene which is known to be over expressed and dysregulated in hematological and solid tumors suggesting that inhibition of Pim-1 signaling could provide patients with therapeutic benefits. Herein, we describe our effort towards this goal by using molecular modeling Methods. We have designed (64) compounds derived from 2-(3, 4-dihydro-1-Benzopyran) acetic acid (compound 5). The docking study with Pim-1 crystal structure was performed by using CDocker and Ligand fit docking Methods. Then hits were filtered based on
Pim-1, hinge region, tumors, benzopyran, CDocker, Ligand fit, ADMET
