Research Journal of Pharmacy and Technology

Aeromonas hydrophila is abundant in freshwater environments, especially with high organic matter content. This bacterial infection is opportunistic, which is an infection that usually does not cause disease in animals with normal immune systems, but can attack animals with poor immune systems. Aeromonas hydrophila infection can be recognized for their external wounds (ulcers), mucus dries up, there are patches of bleeding in a latero-ventral region of the body and fins and scales chipped. Research on Outer Membrane Protein (OMP) has been studied in an attempt to obtain a reliable antigen both for diagnosis and for vaccines. In this study, the authors wanted to do research on the reactivity of the Outer Membrane Protein (OMP) Aeromonas hydrophila in New Zealand rabbits with Immunohistochemistry techniques to investigate the interaction of antibodies with antigens in spleen, liver, and kidney of New Zealand rabbits microscopically. The results will be obtained in this study in the form of spleen, liver, and kidney histopathology tissue images that showed the bond between antigens with antibodies with immunohistochemical techniques that visualized with a brownish color.