NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India
Si-RNA based therapy have promising effect in cancer therapeutics. Still numerous challenges hinders its stable and effective delivery. Nanocarriers could be a better option for efficient, safe and stable delivery of siRNA into cancerous cells. Present review deals with gene therapy and new trends in si-RNA delivery for prevention of cancer which can be more effective, safe and easy to synthesis. Gene therapy is a powerful tool because cancer is related to genetic information of the cell. Delivery of nucleic acid (DNA, RNA) for silencing abnormal genetic activity of cell is the best option for treatment of cancer. The carriers used to deliver siRNA such as vesicular systems, polymeric nanoparticles, lipid based nanoparticles, cyclodextrin polymers, dendrimers and carbon nanotubes are mainly described for si-RNA delivery in this review article. Many carriers are in development pipeline for siRNA delivery.
siRNA, gene silencing, targeted delivery, cancer, carrier
