Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2018
  • Volume: 11
  • Issue: 7

In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity

PG and Research Department of Biochemistry, S.T.E.T.Women's College, Sundarakottai, Mannargudi–614001. Tamil Nadu, India

Abstract

The In vivo antioxidant and modulating enzymes of the Wattakaka volubilis leaves and kaempferol against aluminium sulphate induced toxicity in rats.

Hepatotoxic rats were treated with methanol extract of Wattakaka volubilis and kaempferol for a period of 14 days.

The activities of LPO, SOD, CAT, GSH, GR, GPx and membrane bound enzymes, Mitochondrial enzymes in liver. The activities of all parameters registered a significant (p≤0.001) alteration in aluminium sulphate treated rats, which were significantly recovered towards an almost normal level in rats co-administered with Wattakaka volubilis extract in a dose-dependent manner. All the biochemical investigations were confirmed by the observations and compared with the standard drug silymarin.

Antioxidant enzymes, membrane bound ATPase, mitochondrial TCA cycle enzymes enzymes modulated by kaempferol on aluminium sulphate induced liver toxicity.

Keywords

Antioxidants, free radicals, hepatoprotection, Wattakaka volubilis, Mitochondrial enzymes, membrane bound enzymes