Research Journal of Pharmacy and Technology

Orally administered gastro retentive dosage forms draws great attention in the pharmaceutical research industry. These systems improved patient compliance with increased therapeutic index of drugs increase importance of gastro-retentive drug delivery systems (GRDDS). Numerous physiological constraints associated with gastroretentive dosage forms such as short gastric retentive time, variations in gastric emptying time can be reduced by various technological advanced utilized in the design and fabrication of gastroretentive dosage. Currently different development approaches are utilized to increase gastric retention time, including High density systems, Expanding systems, Unfoldable and Swellable systems and Superporous hydrogels. The present review briefly addresses various gastroretentive dosage forms for prolongation gastric residence time.