1Department of Pharmacy, Faculty of Allied Health Sciences, Mahatma Jyoti Rao Phoole University, Achrol, Jaipur, India
2Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Ladiwali Village, Karjat, Maharashtra, 410201
Cisplatin is an alkylating agent which is used to treat a number of cancers. It is generally used in the treatment of advanced bladder cancers, liver cancer, metastatic ovarian cancers, and metastatic testicular cancer. It is also used in other cancers like, testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. However, apart from its usage in variety of cancers it has side effects too. The major ones are kidney toxicity and Ototoxicity (hearing loss). However, these side effects can be reduced by using novel carriers like liposomes, which may affect its kinetics and enhance its half-life too.
Cisplatin, Liposomes, Tangential Flow filtration, Extrusion, Entrapment efficiency
