Research Journal of Pharmacology and Pharmacodynamics

  • Year: 2015
  • Volume: 7
  • Issue: 3

Hepatoprotective Activity of Stem Bark of Nyctanthes arbor-tristis linn

1Columbia College of Pharmacy, Raipur-493111, C.G., India

2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, C.G., India

3TIT College of Pharmacy, Bhopal-462001, M.P., India

Abstract

The present study is to evaluate the hepatoprotective effects of the 50% hydro-ethanol (Heena) extracts of stem bark of Nyctanthes arbor-tristis linn, against paracetamol induced hepatotoxicity in rats. The hepatoprotective effects of HEENA (500 mg/kg) was estimated by liver function test and serum profile. The results revealed that the extract of selected plant produce significant hepatoprotective effect not only by decreasing serum transaminase (SGPT and SGOT), alkaline phosphate and total bilirubin, but also significantly increased the levels of serum proteins (albumin, fibrinogen haeptoglobin, ceruloplasin, transferring etc). The effects of Heena was comparable with standard drug silymarin.

Keywords

Hepatotoxicity; Nyctanthes arbor-tristis linn; Heena; SGPT; SGOT