Research Journal of Pharmacology and Pharmacodynamics

To study the effect of Trainthema decandra on the sexual behavior of male mice and general toxicity study in female mice, from aerial parts of Trianthema decandra an alcoholic extract was prepared and administered (p.o) to male mice for 30 days, after administration their mounting behavior was observed. The alcoholic extract was administered (100, 200 and 400mg/kg) to different groups of male mice and their mounting behavior, mating performance and Number of mounts was determined. The general short term toxicity of the alcohol extract in female mice was also determined as per OECD guidelines no.425. The acute toxicity of alcoholic extract was studied in mice by giving dose up to 2g/kg (p.o.). The control mice received gum acacia in an identical manner. No behavioral changes were observed in mice, hence the drug is considered as safe. The alcoholic extract of Trianthema decandra was found to stimulate the mounting behavior in male mice and decrease in mating latency. When compared to control group animals, Tentex Forte (100mg/kg) and alcoholic extract of Trianthem decandra (200, 400 mg/kg) treated groups have shown significant increase in total number of mounts and decrease in latency at 1,2,3 and 4^th hour time intervals. But alcoholic extract of Trianthem decandra with 100mg/kg treated group has not shown any significant increase in number of mounts but decreased mounting latency at 1,2,3 and 4^th hours. The alcoholic extract of Trianthema decandra has shown significant effect which were indicated by decreased in mounting latency and increase in the number of mounts when compared with control and standard group.