Research Journal of Pharmaceutical Dosage Forms and Technology

The present study was undertaken to develop controlled porosity osmotic pump tablets of zidovudine-lamivudine combination. The tablets were prepared by wet granulation method using HPMC E5LV, and osmogen was prinicipal ingredients a dose of 300mg zidovudine-150 mg lamivudine twice daily. The coating solution of core tablets were prepared by using cellulose acetate, poly ethylene glycol of different grades, sorbitol and acetone to quantity sufficient for different batches. The prepared tablets were evaluated for pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among developed formulations CS4 batch show 96.31% drug release in 8 h for zidovudine and 97.83% for lamivudine in 8 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon-Crowell model. The result of optimized formulation was independent of the pH and agitation intensity. Short term stability study (at 40±2ºC/75±5% RH for three months) on the best formulation indicated that there were no significant changes in thickness, friability, weight variation, drug content and in vitro drug release.