Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra-India-415404
Solubility and dissolution rate enhancement from solid oral dosage form is a key issue for current formulation and development. This review discusses, out of several techniques available, liquisolid system to improve dissolution rate of water insoluble drugs and to enhance dissolution rate of water soluble drugs. Different carriers and coating materials like Avicel pH 102, and Aerosil 200 can be used as carrier materials to prepare liquisolid system. Various non-volatile solvents like propylene glycol, Polysorbates 80, Glycerin and fixed oils can be used to dissolve water insoluble molecules. Liquid drugs can be mixed directly with carriers to produce liquisolid systems. Liquisolid systems can be used to either enhance or retard drug release.
Solubility enhancement, Liquisolid compact, Liquid medication, mathematical model
