1PG Students, Indian Veterinary Research Institute, Izatnagar-243 122, UP
2Division of Bacteriology and Mycology, Indian Veterinary Research Institute, Izatnagar-243 122, UP
3Scientist, Indian Veterinary Research Institute, Izatnagar-243 122, UP
4Principal Scientist and Head, Indian Veterinary Research Institute, Izatnagar-243 122, UP
5Scientist Emeritus, Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar-243 122, UP
We investigated the effect of betulinic acid (BA) pretreatment on septic-kidney damage using cecal ligation and puncture (CLP) model in mice. Study used 5 groups each consisting of 6 mice. Sham control, CLP control and three CLP groups pretreated with BA at 3, 10 and 30 mg/kg dose. Animals were euthanized at 18 h, plasma and kidney samples were obtained for further investigation. CLP caused a significant decrease in mean survival time, T-SH levels; rise in kidney 8-isoprostane, plasma blood urea nitrogen, MPO levels and marked histopathological changes which were restored by BA pretreatment. BA partially restored kidney damage as revealed by amelioration of few vandalized biochemical parameters due to CLP. Further, definitive studies are required to find out the possible mechanisms underlying the beneficial effects of BA in this model.
Betulinic acid, Kidney, Mice, Sepsis
