1Reader, Department of Periodontics, Sree Balaji Dental College & Hospital, Velachery Main Road, Pallikaranai, Chennai, Tamilnadu, India
2Professor, Department of Periodontics, Sree Balaji Dental College & Hospital, Velachery Main Road, Pallikaranai, Chennai, Tamilnadu, India
Compliment system is tradionally known as a cascade of anti microbial proteins in the blood. It is recognised as a key system for immune surveillance and homeostastis. It has a major link between the innate and the adaptative arms of the host immune response. They exist as pro enzymes and circulate as inactive forms. On activation, they become active, acquire enzymatic or esterase activity, react in particular sequence and cause damage to the neighbouring cells. This review discusses about the dysbiotic transformation of the periodontal pathogens that lead to destructive mechanism and loss of periodontal bone support.
Complement cascade, haemostasis, immunological surveillance toll like receptors, gingipains
