Indian Journal of Animal Research

SCOPUSWeb of Science
  • Year: 2022
  • Volume: 56
  • Issue: 8

α-bisabolol Exerts Anti-inflammatory Action and Ameliorates Collagen-induced Arthritis in Rats

  • Author:
  • Xi Gao1,, Yanli Zhang2,, Wentao Wang3, Zhiwen Zhang1, Chen Li1, Hongjun Lou4,
  • Total Page Count: 7
  • Page Number: 1010 to 1016

1Department of the Fourth Orthopedics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.

2Experimental Teaching and Practical Training Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.

3Department of Orthopedics of Integration TCM with Western Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.

4Department of Clinical Laboratory, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, China.

Abstract

Development of synovial hypertrophy, articular tissue inflammation and tenderness in joints is the characteristic feature of rheumatoid arthritis. Drugs that are derived from natural sources which target inflammation with reduced side-effects receive much attention. Hence, the present study was designed to investigate the anti-arthritic effects of α-bisabolol, a natural chamomile essential oil and also an anti-inflammatory molecule on the rat model of collagen-induced arthritis (CIA).

Animal model of CIA was established and orally administered with α-bisabolol (100 mg/kg) or vehicle and the pathological and inflammatory parameters were evaluated.

The results of the present findings indicate that α-bisabolol treatment ameliorates CIA-induced inflammation via inhibiting the proteases and inflammatory mediators suggesting that α-bisabolol may be a potential candidate against arthritis inflammations.

Keywords

α-bisabolol, Collagen-induced arthritis, Inflammation