Asian Journal of Research in Pharmaceutical Science

  • Year: 2016
  • Volume: 6
  • Issue: 3

Synthesis and Evaluating Anti-Inflammatory, Antibacterial activity of substituted benzylidene Thiazolidinediones

Department of Pharmaceutical Chemistry, NIMS University, Shobha Nagar, Delhi Highway, Jaipur, 303121, Rajasthan

Abstract

This compound we synthesize by a Knoevenagel condensation of 4-aminobenzaldehyde with compound (I) in presence of sodium acetate, but this compound do not comply with the primary aromatic amine test like nitrous acid test and carbylamine test as well as H1 NMR spectra, in this reaction the amine group of benzaldehyde was further reacted another molecules of aldehydes. We modified the process and synthesized compound (Ia), the nitro group of compound Ia was converted in amino group by reduction.

Keywords

Thiazolidinedione, benzaledhyde, Schiff base