Asian Journal of Research in Chemistry

  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives

  • Author:
  • Raga Basawaraj, Majid Shabbir
  • Total Page Count: 5
  • DOI:
  • Page Number: 440 to 444

Post-Graduate Centre, Dept. of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403

Abstract

2-Arylamino/arylidinehydrazino-4-(4-methoxyphenyl-2-yl) thiazoles were obtained by the reaction of 1-bromoacetyl-4-methoxyphenyl with various substituted arylthioureas and arylidinethiosemicarbazides in ethanol. Aminogroup of aryl thiazole have been treated with different aromatic aldehydes afford corresponding schiff bases, which on further treated with chloroacetylchloride and mercaptoacetic acid converted to corresponding azetidinones and thiazolidinones. All the compounds were characterized on basis of analytical and spectral data and these compounds were screened for invitro antimicrobial activity.

Keywords

Arylthiazole, Schiff's bases, Azetidinones, Thiazolidinones, Antimicrobial activity