Asian Journal of Research in Chemistry

  • Year: 2019
  • Volume: 12
  • Issue: 2

An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme

  • Author:
  • Kishore Gokavarapu1,, Rahul Uttamrao Devkar1, Sarita Gokavarapu3, Shiva Rama Krishna Samala2, Durga Prasad Rao3
  • Total Page Count: 3
  • Page Number: 55 to 57

1Production Department, Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

3QC and ADL Department-Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

2Research and Development Department, Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117

Abstract

The present paper describes the CAL-B (Enzymatic) Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70–75% overall yield.

Keywords

Pregabalin, CAL-B, Enantioselective, Enzyme, Hydrolysis