Asian Journal of Research in Chemistry

  • Year: 2019
  • Volume: 12
  • Issue: 1

A Green and Environmentally Friendly, An Improved Synthesis of Pimavanserin (5-HT2A Receptor)

  • Author:
  • Rajesh Kumar Rapolu1,2,, V.V.N.K.V. Prasada Raju1, Murthy Chavali2, Naveen Mulakayala3
  • Total Page Count: 5
  • Page Number: 41 to 45

1Granules India Limited-R & D Center, Plot No.56, Road No.5, ALEAP Industrial Area, Pragathinagar, Hyderabad, 5000072, India

2Division of Chemistry, Department of Science and Humanities, Vignan's Foundation for Science Technology and Research University (VFSTRU), Vadlamudi, Guntur, 522 213, India

3SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad, 500090, India

Abstract

Water mediated and environmentally friendly, step-wise an improved synthesis of pimavanserin have been developed from the key intermediate of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methyl piperidin-4-yl) thiourea at different solvent conditions. These reactions have an easy workup; provide good to excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign and no need of column chromatography for product isolation.

Keywords

Pimavanserin, Parkinson disease, Nuplazid, dopamine receptor