Asian Journal of Research in Chemistry

The final stage synthesis of Sorafenib API required two key intermediates i.e., methyl-3-(4aminophenoxy)benzoate (I) and 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate(II), out of these two intermediates (I) is common and (II)is isocyanate intermediate, which is highly hazardous and creates lung problems while handling, to avoid these health, safety and environment issues instead of isocyanate we have used alternate intermediates which are different types of carbamates(III-VI), using these alternate carbamates intermediates synthesized sorafenib API with good yield and purity avoiding hazardous, synthesized these carbamates and final API were characterized by spectral data by ¹H NMR, ¹³CNMR and HRMS.