Asian Journal of Research in Chemistry

  • Year: 2018
  • Volume: 11
  • Issue: 4

N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Sunstituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones

  • Author:
  • Srishylam Vadde1, N. Devanna1, S. Shiva Rama Krishna2, R Sreenivasulu2, Naveen Mulakayala3
  • Total Page Count: 7
  • Page Number: 739 to 745

1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India

2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901

3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India

Abstract

A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4, 3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.

Graphical abstract:

Keywords

Pyrazolo[4, 3-d]pyrimidin-7(6H)-ones, N-Bromosuccinamide and metal free oxidative cyclisation