Asian Journal of Research in Chemistry

Heterocyclic chemistry has become one of the most important fields of research in pharmaceutical industry due to their many fold applications. Amongst all, heterocyclic molecules containing nitrogen and oxygen (like oxadiazole ring system) have shown most potent biological activities. Microorganisms are strictly attendant with the fitness and well-being of human beings. The present treatments of bacterial and fungal infections are a bit unsatisfactory, owing to rapidly developing drug resistance and side effects. The improved of antibacterial and antifungal agents results in resistant to drugs. A series of substituted Oxadiazoles analogues 4a-jwere synthesized and screened for their antibacterial and antifungal activities to evaluate zone of inhibition. The significant effect ofin-vitroantimicrobial and antifungal activities of compounds 4a-jwere studied using one way ANOVA. It was shown that the variables 4a-j series weresignificant. Further pairwise comparison of significant differences between the variables were analyzed using Tukey HSD. The data revels that compound 4a with 2-methyl and 3chloro group in phenyl and benzoyl ring respectively, have shown excellent activity and more potent among the 4a-j series.