Asian Journal of Research in Chemistry

Quinazoline, a heterocyclic compound, has been extensively studied and used in certain specific biological activities. The quinazoline-4(3H)-one and its derivatives constitute an important class of fused heterocycles that are found in more than 200 naturally occurring alkaloids. With a passage of time, newer and more complex variants of the quinazolinone structures are being discovered. The stability of the quinazolinone nucleus has inspired researchers to introduce many bioactive moieties to this nucleus to create new potential medicinal agents. They exhibit broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Here in this research, we are dealing with the antimicrobial activity of various 3phenyls substituted quinazolin 4-(3H)-one.