Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner-424206, Maharashtra, India
The aim of the study was to prepare and evaluate orodispersible tablet of antimigraine drug naratriptan HCl which is highly appropriate as it has ease of administration for mentally ill, disabled and uncooperative patients. The ODT's were prepared by direct compression method using croscarmellose sodium & crospovidone as superdisintegrants. There were no drug excipient interaction observed by FTIR & DSC. The drug & excipient were compatible with each other. Finally it was concluded that F5 batch prepared by using 2.5% w/w croscarmellose sodium showed 99.98% release of drug over a period of 15 min. while D.T 26 seconds. It passes dispersibility test also F5 batch was also compared with marketed tablets of naratriptan HCl F5 batch showed better release of drug as compared to marketed tablet.
Naratriptan HCl, ODT, Croscarmellose sodium, Crospovidone, Direct compression
