Asian Journal of Pharmacy and Technology

A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in vitro models, which make them imperative tools for finding functional properties, pathological states, and developmental studiesoforgans. Developments in micro-and nanofluidic technologies have led to new kinds of cell culture and screening systems that are collectively termed organ-on-a-chip systems. Organ-on-a-chip systems are in vitro micro fabricated devices that mimic dynamic interactions of in vivo microenvironments.