Asian Journal of Pharmacy and Technology

In this study for solid lipid nanoparticles prepared technique is by microemulsion. Initially, o/w microemulsion was synthesized. The glyceryl tripalmitate (GTP) is oil phase. Lipophilic surfactant as Soy lecithin and and in continuous phase, hydrophilic surfactant (Pluronic F-68) solution was used. Drug was added under stirring after soy lecithin was melted at 70oC, Pluronic F-68 as aqueous surfactant solution about 10mL added by maintaining same temperature to the liquefies lipid with continuous automatic stirring for 15 minutes. When the temperature was close to the melting point of the lipid in the formulation a clear microemulsion was obtained under stirring. To induce positive charge, stearyl amine is used and loaded to melted lipid. Continuous stirring of solid lipid nano particles were attained by dissipating the tepid o/w microemulsion drop wise into freezing water in a glass beaker. After complete addition of microemulsion, SLN dispersion was further stirred. Ultrasonication was carried out for 15 minutes for SLN formulation, then centrifuged and freeze dried. The optimized batch was also evaluated for various parameters such as particle size, zeta potential and surface morphology. Also, optimized formulation was compared for in vitro drug release with drug solution.