Asian Journal of Pharmacy and Technology

The primary benefit of a sustained release dosage form compared to a conventional dosage form, is the uniform drug plasma concentration and therefore uniform therapeutic effect. Matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. The objective of the present study was to develop, evaluate and compare once-daily sustained release matrix tablets of Atomoxetine HCL using Xanthan gum, Karaya gum, Ethyl cellulose and HPMC K 100 polymers. The matrix tablet formulations were prepared by using different drug: polymer ratios (1: 1, 1: 2, and 1: 3). The prepared matrix tablets were evaluated for various parameters like hardness, thickness, weight variation, friability, percent drug content and in vitro drug release studies as per IP guidelines. Out of 12 formulations, the formulation F5 is selected as best formulation which shows 98.56% drug release in 12 hrs.