Asian Journal of Pharmaceutical Research

The present study deals with synthesis of N-Mannich bases of (2-Substituted Phenyl) Benzimidazole derivatives and their spectral characterization by means of UV, IR and 1H NMR. Anti-bacterial activity and antifungal activity were carried out by cup-plate method using Bacillus Subtilis, Protease, Escherichia Coli and Staphylococcus Aeruginosa organisms for antibacterial activity, and Aspergillus Niger fungal organism for antifungal activity. The potency of the synthesized compounds was determined against standard drugs Ciprofloxacin Clotrimazole by measuring the zone of inhibition. The resulted synthesized compounds (H11 to H20) were screened for antibacterial activity and antifungal activity. The synthesized compounds were found to possess moderate to weak activity although several 2-phenyl benzimidazole derivatives (Compounds H11, H13, H17, H18 and H20) were reported for good antibacterial, antifungal activity. The compound H11, H13 and H20 were active against all organisms. Reaming compounds show moderate activity. Whereas the compounds H11, H13, H17 and H18 were active against Aspergillus Niger rest of the compounds showed only weak activity when compared to the standard Ciprofloxacin, Clotrimazole.